Parker's next role was in a movie adaptation of another Craig Lucas play, Reckless (1995), alongside Mia Farrow, followed by Jane Campion's The Portrait of a Lady (1996), which also starred Nicole Kidman, Viggo Mortensen, Christian Bale, John Malkovich and Barbara Hershey.
She starred along side Sidney Poitier in the 1999 movie The Simple Life of Noah Dearborn.
On December 7, 2003, HBO aired a six-and-a-half-hour adaptation of Tony Kushner's acclaimed Broadway play Angels in America, directed by Mike Nichols.
Parker played Harper Pitt, the Mormon Valium-addicted wife of a closeted lawyer.
Mary-Louise Parker (born August 2, 1964) is an American actress and author.
Best known for her lead role on Showtime's television series Weeds portraying Nancy Botwin, she received the Golden Globe Award for Best Actress in 2006.
Parker has appeared in films and series including RED, RED 2, Fried Green Tomatoes, Boys on the Side, The West Wing, and Angels in America, for which she received a Golden Globe and an Emmy Award for Best Supporting Actress.Parker is also the recipient of the 2001 Tony Award for Best Actress for her performance in the Broadway play Proof.Parker got her start in acting with a role on the soap opera Ryan's Hope. After a few minor roles, she made her Broadway debut in a 1990 production of Craig Lucas' Prelude to a Kiss, playing the lead role of Rita.She moved with the production when it transferred from its origin Off-Broadway.Parker won the Clarence Derwent Award for her performance and was nominated for a Tony Award (although she did not play the role when the film was made).Parker starred with Kevin Kline in Grand Canyon (1991); with Kathy Bates, Mary Stuart Masterson, and Jessica Tandy in Fried Green Tomatoes (1991); with Susan Sarandon and Tommy Lee Jones in The Client (1994); with John Cusack in Bullets over Broadway (1994); and with Drew Barrymore and Whoopi Goldberg in Boys on the Side (1995), as a woman with AIDS.